No 404s

How minimizing the Number of iframes improves Web site download performance

HTTP requests are expensive so making an HTTP request and getting a useless response (i.e. 404 Not Found) is totally unnecessary and will slow down the user experience without any benefit.
Some sites have helpful 404s "Did you mean X?", which is great for the user experience but also wastes server resources (like database, etc). Particularly bad is when the link to an external JavaScript is wrong and the result is a 404. First, this download will block parallel downloads. Next the browser may try to parse the 404 response body as if it were JavaScript code, trying to find something usable in it.